The Effect of Prunus amygdalus var. amara Essential Oil on Suppressing Morphine-Induced Cell Death via Inhibition of Inflammatory Cytokines and Nitric Oxide Production

Our findings indicate that the essential oil derived from Prunus amygdalus var. amara effectively mitigates cell death induced by morphine in PC12 cells. This essential oil demonstrates the ability to inhibit nitric oxide (NO) production. Furthermore, it appears to impede apoptosis by inhibiting Caspase-3 activity, preventing DNA fragmentation, and disrupting the integrity of the mitochondrial membrane.

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Publication Details

Journal
Asian Pacific Journal of Cancer Prevention
Published
2026-01-21
DOI
https://doi.org/10.31557/apjcp.2026.27.1.71
Primary Topic
Neurological Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

The Effect of Prunus amygdalus var. amara Essential Oil on Suppressing Morphine-Induced Cell Death via Inhibition of Inflammatory Cytokines and Nitric Oxide Production

Hossein Zhaleh, Zhila Dinari
Asian Pacific Journal of Cancer Prevention
Neurological Disease Mechanisms and Treatments
article

The Effect of Prunus amygdalus var. amara Essential Oil on Suppressing Morphine-Induced Cell Death via Inhibition of Inflammatory Cytokines and Nitric Oxide Production

Hossein Zhaleh, Zhila Dinari
article en

Abstract

Our findings indicate that the essential oil derived from Prunus amygdalus var. amara effectively mitigates cell death induced by morphine in PC12 cells. This essential oil demonstrates the ability to inhibit nitric oxide (NO) production. Furthermore, it appears to impede apoptosis by inhibiting Caspase-3 activity, preventing DNA fragmentation, and disrupting the integrity of the mitochondrial membrane.

Asian Pacific Journal of Cancer PreventionVol. 27(1)
Razi University (IR), Bu-Ali Sina University (IR)
Academic Center for Education, Culture and Research
Openalex Percentile: Top 84%
Neurological Disease Mechanisms and Treatments
DOIOpen Access PDFOpenAlex
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