Amyloid-related imaging abnormalities (ARIA) in Alzheimer’s immunotherapy: a framework and challenges for global surveillance strategies
Figure 1 Proposed pathophysiology of amyloid-related imaging abnormalities (ARIA). 1 Anti-amyloid immunotherapy promotes clearance of parenchymal amyloid- (A), increasing levels of soluble A (sA).The accumulation of sA in perivascular spaces impairs vascular clearance, triggering perivascular inflammation and blood-brain barrier disruption.This cascade leads to vasogenic oedema and/or sulcal effusion
Authors
- Cun-Jin Zhang
- Fuhua Yan (ORCID: https://orcid.org/0000-0002-5910-1506)
- Na Hu (ORCID: https://orcid.org/0000-0003-2759-1288)
- Xiyue Yang
- Yaou Liu
- Bing Zhang
- Su Lui
- Hui Gao
- Xiaochun Chen
- Sven Haller
- Feng Feng
- Qin Chen
Institutions
- University of Geneva (CH)
- Fujian Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- Shanghai Jiao Tong University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Peking Union Medical College Hospital (CN)
- Ruijin Hospital (CN)
- Beijing Tian Tan Hospital (CN)
- West China Hospital of Sichuan University (CN)
- Nanjing Drum Tower Hospital (CN)
- Centre d'Imagerie BioMedicale (CH)
- Union Hospital (CN)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1136/jnnp-2025-337198
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University