Molecular analysis of carbapenemase-producing Pseudomonas aeruginosa strains in a tertiary care hospital in Riyadh
Carbapenem resistance in the studied P. aeruginosa isolates was predominantly mediated by intrinsic resistance mechanisms, including OXA-50-like and AmpC β-lactamases, together with efflux pump overexpression and permeability defects. True carbapenemases were infrequently detected and were limited mainly to IMP-34 and VIM-28. High-risk clones such as ST235 and ST357 exhibited elevated carbapenem MICs largely independent of carbapenemase production.
Authors
- Ahmed Albarrag (ORCID: https://orcid.org/0000-0002-8829-9371)
- H.A. Alshammari (ORCID: https://orcid.org/0000-0002-8982-7957)
- Ali M. Somily (ORCID: https://orcid.org/0000-0002-9634-6107)
- Sumayh A. Aldakeel
- Jaffar A. Al-Tawfiq
- Ihab M. Moussa
Institutions
- Northern Border University (SA)
- Johns Hopkins University (US)
- Saudi Aramco Medical Services Organization (SA)
- King Saud Medical City (SA)
- King Saud University (SA)
- National Public Health Laboratory (NP)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1016/j.jiph.2026.103159
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00