<scp>OGFRL1</scp> Deficiency Causes Chronic Recurrent Multifocal Osteomyelitis Via Pathologic Osteoclastogenesis, With Therapeutic Response to Tumor Necrosis Factor Inhibitor
This study identified OGFRL1 deficiency as a novel cause of CRMO, highlighted the previously unrecognized role of OGFRL1 in restraining inflammatory responses, and provided novel insights into the pathogenesis and treatment of this autoinflammatory disorder.
Authors
- Jiemin Fu
- Jinbo Wang (ORCID: https://orcid.org/0000-0003-3404-3909)
- Yusha Wang (ORCID: https://orcid.org/0000-0002-6507-5658)
- Xiaomin Yu
- Wen Xiong
- Ying Luo
- Jun Yang
- Jun Wang
- Tingyan He
- Qing Zhou
Institutions
- Sir Run Run Shaw Hospital (CN)
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
- Shenzhen Children's Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1002/art.70057
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00