Long-term cardiac effects of adrenalectomy versus surveillance in mild cortisol excess: 5-year results from the prospective ITACA study
MACS is associated with early concentric LV remodelling that regresses after adrenalectomy but rebounds within 5 years, leaving surgical and surveillance patients with comparable cardiac geometry. Under AS, remodelling stabilizes, whereas NFA continue a slow, progressive hypertrophic course. These findings support serial echocardiographic monitoring and underscore the need to test other cortisol-lowering therapies, alone or in combination with surgery, for durable cardioprotection.
Authors
- Dario De Alcubierre (ORCID: https://orcid.org/0000-0001-5242-1761)
- Aurora Labbro Francia
- Valeria Hasenmajer (ORCID: https://orcid.org/0000-0003-4301-6662)
- Ilaria Lospinuso
- Federica Moscucci (ORCID: https://orcid.org/0000-0002-9385-9097)
- Marta Tenuta (ORCID: https://orcid.org/0000-0002-7476-0737)
- Dr Emilia Sbardella
- Riccardo Pofi
- P. Isidori
- Alessandro M Paganini
- Alessandra Tomaselli
- Elisabetta Vozza
- Marianna Minnetti
- Ilaria Bonaventura
- Davide Ferrari
- Evaristo Ettorre
Institutions
- Policlinico Umberto I (IT)
- Churchill Hospital (GB)
- Istituto Neurologico Mediterraneo (IT)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1093/ejendo/lvag018
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 0.00