Comparative effect of vortioxetine and sertraline on clinical and inflammatory profile in Parkinson’s disease with comorbid depression

These data evaluate for the first time the immunomodulatory effects of two different treatments in PD patients with comorbid depression, highlighting the greater immunomodulatory capacity of vortioxetine.

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Publication Details

Journal
Frontiers in Neuroscience
Published
2026-01-22
DOI
https://doi.org/10.3389/fnins.2026.1761550
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparative effect of vortioxetine and sertraline on clinical and inflammatory profile in Parkinson’s disease with comorbid depression

Antonella Moschillo, Domiziana Rinaldi, Daniela Caissutti, Edoardo Bianchini et al.
Frontiers in Neuroscience
Tryptophan and brain disorders
article

Comparative effect of vortioxetine and sertraline on clinical and inflammatory profile in Parkinson’s disease with comorbid depression

Antonella Moschillo, Domiziana Rinaldi, Daniela Caissutti, Edoardo Bianchini, Francesco E. Pontieri, Marika Alborghetti, Fabiana Giada Radicati, Marco Salvetti, Ferdinando Nicoletti, Antonella Capozzi, Martina Marino, Camilla Moliterni, Isabella Berardelli
article en

Abstract

These data evaluate for the first time the immunomodulatory effects of two different treatments in PD patients with comorbid depression, highlighting the greater immunomodulatory capacity of vortioxetine.

Frontiers in NeuroscienceVol. 20
Istituto Neurologico Mediterraneo (IT), IRCCS Ospedale San Raffaele (IT), Sapienza University of Rome (IT), Université Grenoble Alpes (FR)
Good health and well-being
Openalex Percentile: Top 80%
Tryptophan and brain disorders
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Comparative effect of vortioxetine and sertraline on clinical and inflammatory profile in Parkinson’s disease with comorbid depression — Antonella Moschillo, Domiziana Rinaldi, et al. · Frontiers in Neuroscience (2026) | TGRS Research Map | TGRS