Left ventricular global longitudinal strain impairment during long-term hydroxychloroquine exposure

This is the first study highlighting the association between long-term HCQ-ED and systolic dysfunction assessed by GLS in asymptomatic patients. Because of its poor prognosis, early detection of AMIC is necessary, and GLS could be an interesting tool in the screening strategy for the detection of pre-clinical alterations.

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Publication Details

Journal
International Journal of Cardiology
Published
2026-01-22
DOI
https://doi.org/10.1016/j.ijcard.2026.134191
Primary Topic
Drug-Induced Ocular Toxicity
Type
article
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article

Left ventricular global longitudinal strain impairment during long-term hydroxychloroquine exposure

E. Collet, G Laurent, Martin Nivet, J. Maillefert et al.
International Journal of Cardiology
Drug-Induced Ocular Toxicity
article

Left ventricular global longitudinal strain impairment during long-term hydroxychloroquine exposure

E. Collet, G Laurent, Martin Nivet, J. Maillefert, C. Guenancia, Romain Didier, G. Müller, J.C. Eicher, Bernard Bonnotte
article en

Abstract

This is the first study highlighting the association between long-term HCQ-ED and systolic dysfunction assessed by GLS in asymptomatic patients. Because of its poor prognosis, early detection of AMIC is necessary, and GLS could be an interesting tool in the screening strategy for the detection of pre-clinical alterations.

International Journal of CardiologyVol. 449
Inserm (FR), Université de Bourgogne (FR), Université Bourgogne Franche-Comté (FR), Maison des Sciences sociales et des Humanités de Dijon (FR)
No poverty
Openalex Percentile: Top 81%
Drug-Induced Ocular Toxicity
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