Effects of estradiol, tamoxifen, and raloxifene on human temporal lobe cortex astroglial cell spreading
Estradiol, tamoxifen, and raloxifene - widely used hormonal agents - were associated with distinct effects on astrocyte morphology in human cortical tissue. These findings support a role for estrogen receptor modulation in astroglial structural regulation and suggest a potential cellular mechanism contributing to central nervous system symptoms reported in clinical settings.
Authors
- Ahmed Fadiel (ORCID: https://orcid.org/0000-0002-5759-6891)
- Frederick Naftolin (ORCID: https://orcid.org/0000-0002-9447-6266)
- Anne Williamson (ORCID: https://orcid.org/0000-0002-7421-9625)
- Spencer Dd
- Ivaldo Silva
- Vinicius Oliveira Santana
- Howard J. Li
Institutions
- Yale University (US)
- University of Chicago (US)
- United BioSource Corporation (United Kingdom) (GB)
- Indiana University Bloomington (US)
- Health and Human Development (2HD) Research Network (CM)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Gynecological Endocrinology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1080/09513590.2026.2618881
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00