The Secondary Motor Cortex Encodes Aversive Signals and Exerts an Inhibitory Control of Motor Sequence Learning in Mice
M2 neurons encode aversive signals that functionally devalue rewards, thereby reducing motivation and inhibiting motor sequence learning. These results identify M2 as a critical node in neural circuits that adaptively gates motor output based on negative motivational valence.
Authors
- Qionghui Cai
- Yan He (ORCID: https://orcid.org/0000-0003-3614-9301)
- Xinran Pan
- Linshan Huang
- Zhimo Yao (ORCID: https://orcid.org/0000-0002-2465-9622)
- Yang Ruan
- Qin Wang (ORCID: https://orcid.org/0000-0003-1115-4905)
- S. Zhou
- Yan Li
- Liping Zhang
- Jiang‐Fan Chen
Institutions
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Jinhua University of Vocational Technology (CN)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1111/apha.70164
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00