METTL16-m6A-PGC-1α axis contributes to exercise-induced mitochondrial adaptations in skeletal muscle of high-fat diet-fed insulin-resistant mice
In conclusion, METTL16 functions as an exercise-responsive m<sup>6</sup>A methyltransferase that may modulate PGC-1α, mitochondrial function, and insulin-related signalling in HFD skeletal muscle, implicating the METTL16-m<sup>6</sup>A-PGC-1α axis in exercise-induced metabolic adaptations.
Authors
- Meijin HOU
- Weilin Liu (ORCID: https://orcid.org/0000-0001-7212-3147)
- Qing Xiang (ORCID: https://orcid.org/0000-0002-2002-2421)
- Huijuan Wu (ORCID: https://orcid.org/0000-0003-3920-6375)
- Han Zhou (ORCID: https://orcid.org/0009-0002-2837-7451)
- Cai Jiang
- Chunxiu Huang
- Ying Xu
- Cong Chen
- Xiao Han
- Yue Hu
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Riverside Hospital of Guangxi Zhuang Autonomous Region (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1186/s12915-026-02519-5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00