Multiple Periapical Lesions Influence the Expression of TLR4/NF‐κB Pathway Components and the Development of Hepatic Injuries in Healthy and Chronic Alcohol‐Consuming Rats
Multiple AP led to elevated TLR4, NF-κB, IL-6, and TNF-α levels and significant hepatic alterations including hepatocyte degeneration and necrosis. When combined with alcohol consumption, multiple AP exacerbated ethanol-induced liver damage.
Authors
- Jenif Braga de Souza (ORCID: https://orcid.org/0000-0003-0174-6042)
- Emmanuel João Nogueira Leal Silva (ORCID: https://orcid.org/0000-0002-6445-8243)
- K. P. Pinto
- Luciana Moura Sassone
- Luciana Brandão‐Bezerra
- Renata Heisler Neves
- Isabelle da Cunha Degani
Institutions
- Universidade Unigranrio (BR)
- Universidade do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1111/iej.70104
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro