Dialyzer characteristics are associated with differential effects on intradialytic microvascular tissue perfusion
The results in our study show that this small animal model allows to preclinically evaluate new membrane materials and dialyzer designs <i>in vivo</i>. Our results show that different dialyzer membranes have different effects on microvascular perfusion. Although our analysis suggests a potential role for complement activation, the mechanisms underlying these differences and their clinical significance require further study.
Authors
- Ossama Mahmoud (ORCID: https://orcid.org/0000-0003-0179-2532)
- Alireza Akbari (ORCID: https://orcid.org/0000-0001-7915-3605)
- Mehrshad Moradshahi
- L Hur
- YM Zhang
- BGH Janssen
- CW McIntyre
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- London Health Sciences Centre (CA)
- Chinese PLA General Hospital (CN)
- Tianjin Nankai Hospital (CN)
- Robarts Clinical Trials (CA)
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1097/ms9.0000000000004738
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00