Intermittent Hypoxia Preconditioning Protects Against Ischemic Brain Injury in Mice via a PF4-Dependent Paracrine Mechanism
These findings identify PF4 as a key paracrine mediator of IH-induced neuroprotection and support the therapeutic potential of both IHP and PF4-based interventions for ischemic stroke.
Authors
- Yuning Li (ORCID: https://orcid.org/0000-0002-9605-5692)
- Qianqian Shao
- Zhengming Tian (ORCID: https://orcid.org/0000-0001-6183-4701)
- Zirui Xu
- Yakun Gu
- Feiyang Jin (ORCID: https://orcid.org/0009-0009-5529-1232)
- Yingxia Liu
- Xunming Ji
- Jia Liu
- Mengyuan Guo
Institutions
- Capital Medical University (CN)
- Ministry of Science and Technology (VN)
Publication Details
- Journal
- Stroke
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1161/strokeaha.125.052213
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00