In vitro exposure to the SARS-CoV-2 Spike protein subunit S1 leads to changes in several functional characteristics of human trophoblast cells

We conclude that the Spike S1 subunit induces some changes in trophoblast metabolic parameters that may be of relevance for fetal programming metabolic disease in the adult.

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Publication Details

Journal
Placenta
Published
2026-01-22
DOI
https://doi.org/10.1016/j.placenta.2026.01.015
Primary Topic
COVID-19 Impact on Reproduction
Type
article
Field-Weighted Citation Impact
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article

In vitro exposure to the SARS-CoV-2 Spike protein subunit S1 leads to changes in several functional characteristics of human trophoblast cells

Fátima Martel, Ilda Inácio Rodrigues, Carla Ramalho, Francisca Carmo
Placenta
COVID-19 Impact on Reproduction
article

In vitro exposure to the SARS-CoV-2 Spike protein subunit S1 leads to changes in several functional characteristics of human trophoblast cells

Fátima Martel, Ilda Inácio Rodrigues, Carla Ramalho, Francisca Carmo
article en

Abstract

We conclude that the Spike S1 subunit induces some changes in trophoblast metabolic parameters that may be of relevance for fetal programming metabolic disease in the adult.

PlacentaVol. 175
Universidade do Porto (PT), Hospital de São João (PT), i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
Good health and well-being
Openalex Percentile: Top 82%
COVID-19 Impact on Reproduction
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