The impact of delayed evacuation on the quality of human fetal tissue

Warm ischemia following circulatory arrest is the principal driver of tissue degradation, with RNA and cell viability most affected and DNA relatively preserved. Digoxin alone has minimal effect but accelerates degradation under warm conditions. Minimizing the interval between circulatory arrest and evacuation, and avoiding prolonged exposure to body temperature, may preserve tissue integrity and improve the diagnostic and research utility of HFT.

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Publication Details

Journal
PLoS ONE
Published
2026-01-21
DOI
https://doi.org/10.1371/journal.pone.0328595
Primary Topic
Neonatal and fetal brain pathology
Type
article
Field-Weighted Citation Impact
0.00

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article

The impact of delayed evacuation on the quality of human fetal tissue

Elizabeth Micks, Ian G. Phelps, Mei Deng, D Doherty et al.
PLoS ONE
Neonatal and fetal brain pathology
article

The impact of delayed evacuation on the quality of human fetal tissue

Elizabeth Micks, Ian G. Phelps, Mei Deng, D Doherty, SW Prager, Lucinda A. Cort, Yasmeen Otaibi, Ian A. Glass, Jennifer C Dempsey, Diana R O'Day, Kimberly A Aldinger, Kevin Lee
article en

Abstract

Warm ischemia following circulatory arrest is the principal driver of tissue degradation, with RNA and cell viability most affected and DNA relatively preserved. Digoxin alone has minimal effect but accelerates degradation under warm conditions. Minimizing the interval between circulatory arrest and evacuation, and avoiding prolonged exposure to body temperature, may preserve tissue integrity and improve the diagnostic and research utility of HFT.

PLoS ONEVol. 21(1)
University of Washington (US), Norcliffe Foundation (US)
Seattle Children's Research Institute, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Openalex Percentile: Top 81%
Neonatal and fetal brain pathology
DOIOpen Access PDFOpenAlex
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The impact of delayed evacuation on the quality of human fetal tissue — Elizabeth Micks, Ian G. Phelps, et al. · PLoS ONE (2026) | TGRS Research Map | TGRS