Serinc2-STAT3 protects against doxorubicin-induced cardiotoxicity via promoting mitochondrial bioenergetics
Taken together, it can be concluded that Serinc2 can maintain mitochondrial dynamics and increase mitochondrial bioenergy generation by enhancing STAT3 phosphorylation activity, thereby alleviating oxidative stress, apoptotic responses, and improving doxorubicin-induced cardiac dysfunction.
Authors
- Mian Cheng
- Saeed Kashkooli
- Zheyu Liu
- Tao Liu
- Min Huang
- Shan Hu
- Gang Wu
- Hao Ju
- Manqi Yang
Institutions
- Shanghai Chest Hospital (CN)
- Wuhan University (CN)
- Tongren Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.redox.2026.104045
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 30.07