Immunophenotyping TCF1-expressing TILs: spatial profiling and prognostic value in operable non-small cell lung cancer
Our findings support a more refined framework for TCF1<sup>+</sup> TIL assessment and TCF1 expression across cellular populations in the tumor microenvironment, with implications for prognostication in operable NSCLC.
Authors
- Ioannis G. Panayiotides (ORCID: https://orcid.org/0000-0001-7339-8193)
- Dora Chatzidaki
- Ioannis S. Pateras (ORCID: https://orcid.org/0000-0002-6406-9811)
- Georgios Christodoulopoulos (ORCID: https://orcid.org/0000-0002-2692-8910)
- Vasiliki Anastasopoulou
- Lucy H. Booth
- Apostolos Klinakis (ORCID: https://orcid.org/0000-0002-3923-861X)
- Sophia N. Karagiannis (ORCID: https://orcid.org/0000-0002-4100-7810)
- Sophia Tsoka (ORCID: https://orcid.org/0000-0001-8403-1282)
- Vassilis Georgoulias (ORCID: https://orcid.org/0000-0003-2218-2522)
- Konstantinos Ntostoglou (ORCID: https://orcid.org/0000-0001-9030-7169)
- Argyro Ioanna Ieronimaki
- Ioannis Vamvakaris (ORCID: https://orcid.org/0000-0002-2917-7155)
- Ilias P. Nikas (ORCID: https://orcid.org/0000-0001-8625-2556)
- Eleni Patsea
- Katie Stoker (ORCID: https://orcid.org/0009-0002-7889-7164)
- Teresa Frisan (ORCID: https://orcid.org/0000-0002-1209-0942)
- Anastasia Xagara
- Athanasios Kotsakis
- Jean Descarpentrie
Institutions
- University of Thessaly (GR)
- King's College - North Carolina (US)
- National and Kapodistrian University of Athens (GR)
- Metropolitan Hospital Center (US)
- Breast Cancer Now (GB)
- University of Cyprus (CY)
- Biomedical Research Foundation of the Academy of Athens (GR)
- Chest Diseases Hospital (KW)
- University Hospital of Larissa (GR)
- Department of Physics, Mathematics and Informatics (BY)
- Hellenic Oncology Research Group (GR)
- Metropolitan Hospital (GR)
- Hospital Metropolitano (EC)
- Sotiria General Hospital (GR)
- Umeå University (SE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fimmu.2026.1731337
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00