Immunophenotyping TCF1-expressing TILs: spatial profiling and prognostic value in operable non-small cell lung cancer

Our findings support a more refined framework for TCF1<sup>+</sup> TIL assessment and TCF1 expression across cellular populations in the tumor microenvironment, with implications for prognostication in operable NSCLC.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-22
DOI
https://doi.org/10.3389/fimmu.2026.1731337
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
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article

Immunophenotyping TCF1-expressing TILs: spatial profiling and prognostic value in operable non-small cell lung cancer

Ioannis G. Panayiotides, Dora Chatzidaki, Ioannis S. Pateras, Georgios Christodoulopoulos et al.
Frontiers in Immunology
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Immunophenotyping TCF1-expressing TILs: spatial profiling and prognostic value in operable non-small cell lung cancer

Ioannis G. Panayiotides, Dora Chatzidaki, Ioannis S. Pateras, Georgios Christodoulopoulos, Vasiliki Anastasopoulou, Lucy H. Booth, Apostolos Klinakis, Sophia N. Karagiannis, Sophia Tsoka, Vassilis Georgoulias, Konstantinos Ntostoglou, Argyro Ioanna Ieronimaki, Ioannis Vamvakaris, Ilias P. Nikas, Eleni Patsea, Katie Stoker, Teresa Frisan, Anastasia Xagara, Athanasios Kotsakis, Jean Descarpentrie
article en

Abstract

Our findings support a more refined framework for TCF1<sup>+</sup> TIL assessment and TCF1 expression across cellular populations in the tumor microenvironment, with implications for prognostication in operable NSCLC.

Frontiers in ImmunologyVol. 17
University of Thessaly (GR), King's College - North Carolina (US), National and Kapodistrian University of Athens (GR), Metropolitan Hospital Center (US), Breast Cancer Now (GB), University of Cyprus (CY), Biomedical Research Foundation of the Academy of Athens (GR), Chest Diseases Hospital (KW), University Hospital of Larissa (GR), Department of Physics, Mathematics and Informatics (BY), Hellenic Oncology Research Group (GR), Metropolitan Hospital (GR), Hospital Metropolitano (EC), Sotiria General Hospital (GR), Umeå University (SE)
Openalex Percentile: Top 81%
Cancer Immunotherapy and Biomarkers
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