Saraswata Ghrita mitigates AlCl₃- and D-galactose–induced cognitive deficits in a murine Alzheimer’s-like model: In silico and in vivo insights
SG administration was associated with improved cognition and partial normalization of cholinergic, oxidative, and inflammatory markers in this model. Computational findings support possible AChE engagement but are not definitive; further quantitative histology and standardized-formulation studies are warranted.
Authors
- Bhupesh Sharma (ORCID: https://orcid.org/0000-0002-3423-007X)
- Tanuja Manoj Nesari (ORCID: https://orcid.org/0000-0002-1312-442X)
- Harvinder Singh (ORCID: https://orcid.org/0000-0002-6773-5648)
- Arun Mahapatra
- Pradeep Kumar Prajapati
- Ashok Kumar Patel
- Shivani Ghildiyal
- Robin Badal
- Pramod Yadav
- Balveer Kaur
- Poonam Sharma
- Lalan Kumar
Institutions
- Institute of Management Technology (IN)
- Ayurvedic Institute (US)
- Gujarat Ayurved University (IN)
- Shree Guru Gobind Singh Tricentenary University (IN)
- National Institute of Ayurveda (IN)
- Ministry of AYUSH (IN)
- Desh Bhagat Ayurvedic College and Hospital (IN)
- Dr. Sarvepalli Radhakrishnan Rajasthan Ayurved University (IN)
- Post Graduate Institute of Medical Education and Research (IN)
- Indian Institute of Public Administration (IN)
- Indian Institute of Technology Delhi (IN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.brainresbull.2026.111742
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.00