Evaluation of pan-TRK immunostaining in malignant peripheral nerve sheath tumours: does its positivity indicate <i>NTRK</i> rearrangements or neural differentiation?
This study suggests that pan-TRK immunostaining may be useful for confirming neural differentiation in MPNST. However, whether its positivity reflects <i>NTRK</i> rearrangements or neural differentiation must be carefully assessed in combination with various immunohistochemical and molecular tests.
Authors
- Takeshi Iwasaki (ORCID: https://orcid.org/0000-0001-5277-2932)
- Yuya Ito (ORCID: https://orcid.org/0000-0003-1295-4357)
- Minako Fujiwara
- Shigeo Hara (ORCID: https://orcid.org/0000-0001-9293-2064)
- Sakura Shiraishi (ORCID: https://orcid.org/0009-0000-9471-1708)
- Kenichi Kohashi (ORCID: https://orcid.org/0000-0002-2358-7452)
- Takumi Tomonaga
- Hiroki Sonoda
- Seiya Momosaki
- Yasuharu Nakashima
- Taro Mori
- Yoshinao Oda
- Kenichi Taguchi
Institutions
- Kyushu University (JP)
- National Kyushu Medical Center (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
- Kyushu University Hospital (JP)
- Universidad Metropolitana (VE)
- Kyushu University Beppu Hospital (JP)
- Kobe City Medical Center General Hospital (JP)
- Tokyo Metropolitan University (JP)
Publication Details
- Journal
- Journal of Clinical Pathology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1136/jcp-2025-210513
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00