Elevated serum glucosylsphingosine level in children with obesity: relation to plasma atherogenesis

Serum Lyso-GL-1 is elevated in children with obesity, being closely correlated with hypertension, insulin resistance, and atherogenesis. This could provide a mechanistic insight on the role of Lyso-GL-1 in obesity and atherogenesis. Further studies are warranted to explore the potential role of Lyso-GL-1 as a biomarker and target for the prevention and treatment of obesity-related atherogenesis and insulin resistance.

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Publication Details

Journal
International Journal of Obesity
Published
2026-01-22
DOI
https://doi.org/10.1038/s41366-025-02016-9
Primary Topic
Lysosomal Storage Disorders Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Elevated serum glucosylsphingosine level in children with obesity: relation to plasma atherogenesis

Marwa S. Hamza, R H Mahmoud, Nanies Salah, Dina Abdel Hakam et al.
International Journal of Obesity
Lysosomal Storage Disorders Research
article

Elevated serum glucosylsphingosine level in children with obesity: relation to plasma atherogenesis

Marwa S. Hamza, R H Mahmoud, Nanies Salah, Dina Abdel Hakam, Eman Aly Ramadan, Fatma AbdEllah Abdullah
article en

Abstract

Serum Lyso-GL-1 is elevated in children with obesity, being closely correlated with hypertension, insulin resistance, and atherogenesis. This could provide a mechanistic insight on the role of Lyso-GL-1 in obesity and atherogenesis. Further studies are warranted to explore the potential role of Lyso-GL-1 as a biomarker and target for the prevention and treatment of obesity-related atherogenesis and insulin resistance.

International Journal of Obesity
Ain Shams University (EG), British University in Egypt (EG)
Science and Technology Development Fund
Good health and well-being
Openalex Percentile: Top 82%
Lysosomal Storage Disorders Research
DOIOpen Access PDFOpenAlex
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Elevated serum glucosylsphingosine level in children with obesity: relation to plasma atherogenesis — Marwa S. Hamza, R H Mahmoud, et al. · International Journal of Obesity (2026) | TGRS Research Map | TGRS