Metagenomic next-generation sequencing enables early detection and outcome improvement in perioperative mucormycosis after liver transplantation: A single-center experience

mNGS enables earlier detection of perioperative mucormycosis compared to conventional diagnostic methods and supports timely initiation of targeted therapy. Rapid mNGS-guided intervention may prevent progression to disseminated disease and improve prognosis in liver transplant recipients. Integration of mNGS into the diagnostic workflow is recommended for high-risk patients with unexplained pulmonary or cutaneous lesions.

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Publication Details

Journal
International Journal of Infectious Diseases
Published
2026-01-22
DOI
https://doi.org/10.1016/j.ijid.2026.108419
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.00
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article

Metagenomic next-generation sequencing enables early detection and outcome improvement in perioperative mucormycosis after liver transplantation: A single-center experience

Wei Zhang, Xinyu Yu, Junfang Liu, Rongrong Wang et al.
International Journal of Infectious Diseases
Antifungal resistance and susceptibility
article

Metagenomic next-generation sequencing enables early detection and outcome improvement in perioperative mucormycosis after liver transplantation: A single-center experience

Wei Zhang, Xinyu Yu, Junfang Liu, Rongrong Wang, Ying Chen, Yuntao Zhang, Jiameng Qi, Yue Wu
article en

Abstract

mNGS enables earlier detection of perioperative mucormycosis compared to conventional diagnostic methods and supports timely initiation of targeted therapy. Rapid mNGS-guided intervention may prevent progression to disseminated disease and improve prognosis in liver transplant recipients. Integration of mNGS into the diagnostic workflow is recommended for high-risk patients with unexplained pulmonary or cutaneous lesions.

International Journal of Infectious DiseasesVol. 165
First People's Hospital of Yuhang District (CN), First Affiliated Hospital Zhejiang University (CN)
Good health and well-being
Openalex Percentile: Top 79%
Antifungal resistance and susceptibility
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