Prospective association between the triglyceride-glucose index and frailty in middle-aged and older adults: insights from a nationwide cohort study

Elevated metabolic risk, as evaluated by the TyG index, was prospectively associated with an increased risk of frailty in middle-aged and older adults, although cross-sectional analysis was negative. These results suggest that the TyG index may serve as a valuable biological marker for identifying individuals at risk of future frailty.