JR20, a novel natural product-derived compound, exhibits potent anti-biofilm activity against methicillin-resistant Staphylococcus aureus
This study confirms JR0's potent anti-MRSA activity, clarifies its effects on biofilms and MRSA morphology, and proposes a preliminary mechanism by reduced ATP. JR20 demonstrates significant potential for combating drug-resistant bacteria and advancing antibiofilm drug discovery.
Authors
- 尋道 乗松 (ORCID: https://orcid.org/0009-0008-2310-3949)
- Meirong Zhao (ORCID: https://orcid.org/0000-0003-3132-9223)
- Hedong Bian
- Yifu Guan (ORCID: https://orcid.org/0000-0002-5258-8315)
- ZhenDan He
- Leonard Williams
- Xinrong Xie (ORCID: https://orcid.org/0000-0002-2436-5210)
- Chaowei Zhang
- Dongyu Huang
- Yogini Jaiswal
Institutions
- Hong Kong Baptist University (HK)
- Minzu University of China (CN)
- Shenzhen University (CN)
- North Carolina Agricultural and Technical State University (US)
- Jiangsu Food and Pharmaceutical Science College (CN)
- Shenzhen Technology University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fmicb.2025.1743534
- Primary Topic
- Sesame and Sesamin Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shenzhen City
- National Natural Science Foundation of China