Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1 mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial

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Publication Details

Journal
The Lancet Neurology
Published
2026-01-22
DOI
https://doi.org/10.1016/s1474-4422(25)00426-0
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
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article

Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1 mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial

Kewei W. Chen, R Doody, Margarita Giraldo, Laura Jakimovich et al.
The Lancet Neurology
Dementia and Cognitive Impairment Research
article

Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1 mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial

Kewei W. Chen, R Doody, Margarita Giraldo, Laura Jakimovich, Ernesto Luna, Beth L. Ostaszewski, Jonas Nguyen, Mario Muñoz Collazos, Alejandro Ceja Espinosa, Andres Schneider, M. Castaño, Marisa N. Denkinger, Hugo E. López, Eugenia Cardona, Selkoe Dj, Paula Ospina, Gregorio Sánchez, Veronica Tirado, Sergio Castro Álvarez, C. Gutiérrez Muñoz, Eliana Henao, Gustavo Villegas, Nan Hu, Kaycee M Sink, David Clayton, Pierre N Tariot, Yamile Bocanegra, Nicholas J Ashton, David Aguillon, Yi Ran Xu, Yakeel T Quiroz, Michael Dolton, Silvia Ríos-Romenets, Tobias Bittner, Lon S Schneider, Yi Su, Ronald G Thomas, Yuqi Cai, Robert C Alexander, Natalia Acosta-Baena, Eric M Reiman, Jessica B Langbaum, Victor Poon
article en

Abstract

No abstract available for this paper.
The Lancet NeurologyVol. 25(2)
University of Southern California (US), Roche (Switzerland) (CH), Brigham and Women's Hospital (US), University of Quindío (CO), Harvard University (US), Banner Health (US), Universidad de Antioquia (CO), University of California San Diego (US), Hospital Pablo Tobon Uribe (CO), Human Longevity (United States) (US), Banner Sun Health Research Institute (US), Colombian Association of Surgery (CO), Banner Alzheimer’s Institute
Good health and well-being
Openalex Percentile: Top 81%
Dementia and Cognitive Impairment Research
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