Dynamics of Azithromycin Resistance in Pediatric Haemophilus Influenzae Isolates in Wuhan (2015–2024)

Early-2020 COVID-19-related containment may have coincided with a temporary slowdown in azithromycin resistance, whereas the 2023 MRMP epidemic was associated with a marked surge-consistent with a level drop at 2020 and a non-significant post-2022 slope increase in segmented regression. Inhibition zone diameter appears to provide an early phenotypic warning of resistance shifts. These findings support reassessing empirical treatment choices and strengthening regional resistance surveillance.