METTL3-mediated N6-methyladenosine modification of LEPR is critical for fetal growth restriction
Our study revealed that METTL3 regulated trophoblastic function likely through an m<sup>6</sup>A-LEPR-dependent mechanism in HTR8/SVneo cells and identified a potential biomarker panel for treatment prediction in FGR.
Authors
- Dianjie Li (ORCID: https://orcid.org/0000-0002-9976-7556)
- T. Luo (ORCID: https://orcid.org/0000-0001-5139-5784)
- Jiayi Jiang (ORCID: https://orcid.org/0009-0006-3792-4989)
- Jianhong Chen (ORCID: https://orcid.org/0000-0002-3232-7812)
- Y -W Zhang
- Yixiang Zhong
- Xiangli Chen
- Meng Li
- Jing Li
- Mei Zhong
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- Huizhou Central People's Hospital (CN)
- Jiangmen Central Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Placenta
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.placenta.2026.01.013
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00