ILT4 and its R20H variant as marker of poor prognosis in Spanish patients with colorectal cancer
Patients with colorectal tumors exhibit a high infiltrate of ILT4 + cells within the tumors, and the rs383369-C polymorphism is linked to greater pathological severity. These results support the involvement of ILT4 in the development of colorectal tumors, as well as its potential use as a biomarker and therapeutic target.
Authors
- A. Arnaiz-Villena
- María L. Suárez-Solís (ORCID: https://orcid.org/0000-0001-6856-0221)
- Elena Álvarez-González
- C Sánchez del Pueblo
- José María Mugüerza-Huguet
- José Manuel Martín-Villa
- Christian Vaquero-Yuste
- Sandra Fernández-Uría
Institutions
- Universidad Complutense de Madrid (ES)
- Hospital Clínico San Carlos (ES)
Publication Details
- Journal
- Human Immunology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.humimm.2026.111670
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00