Hypoxic mesenchymal stem cell-Derived Exosomal circPTP4A2 improves granulosa cell mitochondrial function via YBX1
These results establish the circPTP4A2/YBX1 axis as a critical mediator of the therapeutic efficacy of H-Exs for POI, providing both mechanistic insights and a translational framework for exosome-based regenerative strategies.
Authors
- Xiaolan Zhu (ORCID: https://orcid.org/0000-0002-0499-8045)
- Y. Liu
- Xuyan Shi
- Jingjing Lu (ORCID: https://orcid.org/0000-0001-8574-8824)
- Yanting Lv
- Wenxin Li
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Zhenjiang City Fourth People's Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1007/s00018-025-06067-z
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00