Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models
Genetic predisposition contributes to asthma-depression comorbidity through direct effects and shared pathogenic processes. These findings highlight the potential to develop targeted interventions to prevent and treat the co-occurrence of respiratory and neuropsychiatric disorders.
Authors
- Brenda Cabrera‐Mendoza (ORCID: https://orcid.org/0000-0003-4729-9997)
- J.H. Kim (ORCID: https://orcid.org/0009-0000-7979-5691)
- Xueting Wang
- Wen Gu (ORCID: https://orcid.org/0000-0003-1414-0605)
- Jun He
- Youwen Liu
- Dan Qiu
- Renato Polimanti
- Zhongzheng Mao
Institutions
- XinHua Hospital (CN)
- Yale University (US)
- VA Connecticut Healthcare System (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1186/s12916-026-04646-w
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00