Clinical characteristics and whole exome sequencing in <i>JAK2</i> V617F- and <i>CALR</i> -unmutated essential thrombocythemia

Patients with <i>JAK2</i>V617F- and <i>CALR</i>-unmutated ET tend to present at a younger age and exhibit a lower incidence of thrombosis compared to those with <i>JAK2</i>V617F-mutated ET. The application of WES enabled the detection of uncommon and potential driver mutations in <i>JAK2</i>V617F- and <i>CALR</i>-unmutated ET.

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Publication Details

Journal
Hematology
Published
2026-01-21
DOI
https://doi.org/10.1080/16078454.2026.2616933
Primary Topic
Myeloproliferative Neoplasms: Diagnosis and Treatment
Type
article
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article

Clinical characteristics and whole exome sequencing in JAK2 V617F- and CALR -unmutated essential thrombocythemia

Lalita Norasetthada, Sasinee Hantrakool, Pokpong Piriyakhuntorn, Chatree Chai‐Adisaksopha et al.
Hematology
Myeloproliferative Neoplasms: Diagnosis and Treatment
article

Clinical characteristics and whole exome sequencing in JAK2 V617F- and CALR -unmutated essential thrombocythemia

Lalita Norasetthada, Sasinee Hantrakool, Pokpong Piriyakhuntorn, Chatree Chai‐Adisaksopha, Teerachat Punnachet, Jeerawan Klangjorhor, Noppamas Panyasit, Nonthakorn Hantrakun, Ekarat Rattarittamrong, Piangrawee Niprapan, Thanawat Rattanathammethee, Patcharawadee Thongkumkoon, Adisak Tantiworawit, Siraphop Thammayot
article en

Abstract

Patients with <i>JAK2</i>V617F- and <i>CALR</i>-unmutated ET tend to present at a younger age and exhibit a lower incidence of thrombosis compared to those with <i>JAK2</i>V617F-mutated ET. The application of WES enabled the detection of uncommon and potential driver mutations in <i>JAK2</i>V617F- and <i>CALR</i>-unmutated ET.

HematologyVol. 31(1)
Chiang Mai University (TH)
Openalex Percentile: Top 81%
Myeloproliferative Neoplasms: Diagnosis and Treatment
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