The Role of Interferon-γ-Induced Granzyme B in Enhancing Antitumour Immune Responses in Oral Squamous Cell Carcinoma
This study established a robust prognostic model for OSCC based on MHC-related genes and demonstrated that IFN-γ enhances antitumor immunity through GZMB-mediated cytotoxic activation. The IFN-γ-GZMB axis appears to represent a critical regulatory pathway within the OSCC immune microenvironment and provide a promising therapeutic target and mechanistic basis for immunotherapy in OSCC.
Authors
- Zheyi Sun
- Wanyue Zhang
- Weihong Wang
- Lei Feng
- Hongrong Zhang
- Jingyi Li
- Xue Zhou
Institutions
- Kunming Medical University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.identj.2025.109377
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00