Kidney Function Decline in Sickle Cell Disease

In this large, real-world cohort of patients with SCD, RASi use was not associated with slowed eGFR decline. These findings underscore the limitations of observational data and highlight the urgent need for prospective trials to identify effective GFR-preserving therapies for this high-risk population.

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Publication Details

Journal
Kidney360
Published
2026-01-21
DOI
https://doi.org/10.34067/kid.0000001116
Primary Topic
Hemoglobinopathies and Related Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Kidney Function Decline in Sickle Cell Disease

Kabir O. Olaniran, Robert D. Toto, Orson W. Moe, Alecia Nero et al.
Kidney360
Hemoglobinopathies and Related Disorders
article

Kidney Function Decline in Sickle Cell Disease

Kabir O. Olaniran, Robert D. Toto, Orson W. Moe, Alecia Nero, S. Susan Hedayati
article en

Abstract

In this large, real-world cohort of patients with SCD, RASi use was not associated with slowed eGFR decline. These findings underscore the limitations of observational data and highlight the urgent need for prospective trials to identify effective GFR-preserving therapies for this high-risk population.

Kidney360
Southwestern Medical Center (US), Stony Brook University (US), The University of Texas Southwestern Medical Center (US)
Good health and well-being
Openalex Percentile: Top 81%
Hemoglobinopathies and Related Disorders
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Kidney Function Decline in Sickle Cell Disease — Kabir O. Olaniran, Robert D. Toto, et al. · Kidney360 (2026) | TGRS Research Map | TGRS