A single-center culture-based study of Helicobacter pylori in Kazakhstan with regional meta-analysis of prevalence and antibiotic resistance
This study provides the first culture-based evidence of <i>H. pylori</i> infection and antimicrobial resistance in Kazakhstan. The high resistance to metronidazole and clarithromycin suggests a likely lower success of standard triple therapy in Almaty. Absence of resistance to minocycline and sitafloxacin supports their use in rescue regimens. These findings highlight the urgent need for national surveillance, updated treatment guidelines, and integration of molecular resistance monitoring to improve evidence-based management of <i>H. pylori</i> in Central Asia.
Authors
- Jamilya Kaibullayeva (ORCID: https://orcid.org/0000-0002-0783-4441)
- Gulnur Zhunussova (ORCID: https://orcid.org/0000-0001-8642-9577)
- Arailym Yerzhan (ORCID: https://orcid.org/0000-0003-0319-3138)
- Aliya A. Kaisina (ORCID: https://orcid.org/0009-0008-6250-1448)
- Alma Khabizhanova (ORCID: https://orcid.org/0009-0006-5753-1496)
- Kaisar Dauyey
- Aliya Medetbekova
- Yoshio Yamaoka
- Kanat Seitbekov
- Yevgeniya Bondar
Institutions
- Baylor College of Medicine (US)
- Oita University (JP)
- Institute of Molecular Genetics (RU)
- Federal State Scientific Institution Research Institute of Eye Diseases (RU)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fmicb.2026.1747006
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Japan International Cooperation Agency
- Science and Technology Research Partnership for Sustainable Development