Pauci-Immune Endocapillary Proliferative Glomerulonephritis With Glomerular M2 Macrophage Infiltration

Pauci-I-EPGN is a rare distinct entity characterized by abnormal activation of intraglomerular M2 macrophages and CD8+ T cell infiltration, with inflammation-fibrosis imbalance driven by TGF-β overexpression. Corticosteroids may offer a potential therapeutic benefit for this type of disease. The overall outcomes in this cohort were generally favorable.

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Publication Details

Journal
Kidney International Reports
Published
2026-01-22
DOI
https://doi.org/10.1016/j.ekir.2026.103791
Primary Topic
Vasculitis and related conditions
Type
article
Field-Weighted Citation Impact
0.00
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article

Pauci-Immune Endocapillary Proliferative Glomerulonephritis With Glomerular M2 Macrophage Infiltration

Ruimin Hu, Yong Zhong, Ziyang Qiao, Yafen Yu et al.
Kidney International Reports
Vasculitis and related conditions
article

Pauci-Immune Endocapillary Proliferative Glomerulonephritis With Glomerular M2 Macrophage Infiltration

Ruimin Hu, Yong Zhong, Ziyang Qiao, Yafen Yu, Xiaodong Zhu, Ruoyu Jia, Guolan Xing, Dan Zhou, Lijuan Li, Rong Tan, Lei Ma, Zhengyun Zhu, Fan Yang, Yujie Wang, Shaojun Liu, Jing Tian, Meizi Kang, Feng Xu, Xinchen Yao, Caihong Zeng, Shaoshan Liang
article en

Abstract

Pauci-I-EPGN is a rare distinct entity characterized by abnormal activation of intraglomerular M2 macrophages and CD8+ T cell infiltration, with inflammation-fibrosis imbalance driven by TGF-β overexpression. Corticosteroids may offer a potential therapeutic benefit for this type of disease. The overall outcomes in this cohort were generally favorable.

Kidney International ReportsVol. 11(4)
Jiangnan University (CN), Zhejiang Chinese Medical University (CN), Fudan University (CN), Nanjing General Hospital of Nanjing Military Command (CN), Wuxi Fourth People's Hospital (CN), First Affiliated Hospital of Zhengzhou University (CN), Huashan Hospital (CN), Nanjing University (CN)
Zero hunger
Openalex Percentile: Top 82%
Vasculitis and related conditions
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Pauci-Immune Endocapillary Proliferative Glomerulonephritis With Glomerular M2 Macrophage Infiltration — Ruimin Hu, Yong Zhong, et al. · Kidney International Reports (2026) | TGRS Research Map | TGRS