Tongmai Yishen Formula alleviates post-stroke depression by restoring neuronal homeostasis in the lateral habenula via the ITPKA signaling pathway
Dual dysregulation of neuronal excitability and synaptic plasticity in the LHb represents a core pathological feature of PSD. TMYSF exerts potent neuroprotective and antidepressant effects by targeting the ITPKA-βCaMKII/ERK/CREB signaling axis.
Authors
- Feichi Hu (ORCID: https://orcid.org/0009-0001-7373-3454)
- Xiang-Qing Xu
- Xiang-Dong Xu (ORCID: https://orcid.org/0009-0003-5592-3830)
- Yiran Wang (ORCID: https://orcid.org/0000-0002-9062-4751)
- Wenqiang Cui
- Zhen‐Ling Liu (ORCID: https://orcid.org/0000-0003-3889-0363)
- Huai-Qian Bo
- Kaixin Zhang
- Zong-Yan Yin
- Yu-Wang
- Tao Xu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Jimo District Qingdao Hospital of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Qingdao Eighth People's Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1016/j.phymed.2026.157866
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00