Pathogenesis of Pulmonary Artery Remodeling: TGF-Beta Signaling and Inhibin Subunit Beta A in Group 1 and 2 Pulmonary Hypertension
Integrated RNA sequencing and metabolomics with stretched PASMCs and animal models identified mitochondrial dysfunction and subsequent acidic alterations as stimulators of increased INHBA expression and TGF-β signaling. These mechanisms contributed to PA remodeling in group 2 PH and provided potential therapeutic strategies.
Authors
- Taijyu Satoh (ORCID: https://orcid.org/0000-0002-1795-6872)
- Satoshi Miyata (ORCID: https://orcid.org/0000-0003-2400-7525)
- Shinichiro Sunamura
- Kaito Yamada (ORCID: https://orcid.org/0000-0002-1556-607X)
- Nobuhiro Kikuchi (ORCID: https://orcid.org/0000-0002-5382-8886)
- Yusuke Yamada (ORCID: https://orcid.org/0000-0003-2684-516X)
- Saori Yamamoto (ORCID: https://orcid.org/0009-0006-2167-5535)
- Hisashi Oishi (ORCID: https://orcid.org/0000-0002-1381-6362)
- Kohei Komaru
- Nobuhiro Yaoita
- Shunsuke Tatebe
- Hideka Hayashi
- Yoshinori Okada
- Takashi Nakata
- Hiroyuki Takahama
- Naoki Chiba
- Satoshi Yasuda
- Haruka Sato
- Hideaki Suzuki
- Takumi Inoue
Institutions
- Tohoku University (JP)
- Sendai Medical Center (JP)
- Norwegian Womens Public Health Association (NO)
- Institute of Aging (CA)
- Teikyo University (JP)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1161/atvbaha.125.322506
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 72.89