Low‐Dose Aspirin Induced Gastric Ulcer in a Patient With <scp>TIA</scp> : A Clinical Caution for Aspirin Therapy Without Gastroprotection

Balancing the cerebrovascular benefits of low-dose aspirin (LDA) with its significant gastrointestinal (GI) bleeding risk is a critical challenge in secondary stroke prevention. We describe a cautionary case of a 60-year-old male who, 6 months after starting LDA for a transient ischemic attack (TIA), presented with a life-threatening upper GI bleed. The patient had not been prescribed a prophylactic proton pump inhibitor (PPI). Investigations revealed a hemoglobin of 9.6 g/dL and multiple gastric ulcers on endoscopy, with negative testing for <i>Helicobacter pylori</i>. This case of a preventable, severe adverse event serves as a stark reminder that guideline-recommended gastroprotection is not optional but essential. Systematic risk assessment and PPI co-prescription in at-risk individuals are imperative for the safe and effective use of long-term antiplatelet therapy.

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Publication Details

Journal
Clinical Case Reports
Published
2026-01-21
DOI
https://doi.org/10.1002/ccr3.71913
Primary Topic
Antiplatelet Therapy and Cardiovascular Diseases
Type
article
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article

Low‐Dose Aspirin Induced Gastric Ulcer in a Patient With TIA : A Clinical Caution for Aspirin Therapy Without Gastroprotection

Fazeela Bibi, Muhammad Muneeb, Vohra Maham Hassan, Said Hamid Sadat et al.
Clinical Case Reports
Antiplatelet Therapy and Cardiovascular Diseases
article

Low‐Dose Aspirin Induced Gastric Ulcer in a Patient With TIA : A Clinical Caution for Aspirin Therapy Without Gastroprotection

Fazeela Bibi, Muhammad Muneeb, Vohra Maham Hassan, Said Hamid Sadat, Kainat Husain, Aminullah Betanai, Muhammad Ibrahim, Bilal Aslam, Abdullah Saud, Khalil El Abdi
article en

Abstract

Balancing the cerebrovascular benefits of low-dose aspirin (LDA) with its significant gastrointestinal (GI) bleeding risk is a critical challenge in secondary stroke prevention. We describe a cautionary case of a 60-year-old male who, 6 months after starting LDA for a transient ischemic attack (TIA), presented with a life-threatening upper GI bleed. The patient had not been prescribed a prophylactic proton pump inhibitor (PPI). Investigations revealed a hemoglobin of 9.6 g/dL and multiple gastric ulcers on endoscopy, with negative testing for <i>Helicobacter pylori</i>. This case of a preventable, severe adverse event serves as a stark reminder that guideline-recommended gastroprotection is not optional but essential. Systematic risk assessment and PPI co-prescription in at-risk individuals are imperative for the safe and effective use of long-term antiplatelet therapy.

Clinical Case ReportsVol. 14(2)
Mohammed V University (MA), University of Lahore (PK), Khyber Medical College (PK), Jawaharlal Nehru Medical College Hospital (IN), Kabul University (AF), Kabul University of Medical Sciences Abu Ali Ibn Sina (AF), Jinnah Medical & Dental College (PK), Holy Family Hospital (PK), University of Swabi (PK), University of Science and Technology Bannu (PK)
Good health and well-being
Openalex Percentile: Top 82%
Antiplatelet Therapy and Cardiovascular Diseases
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