Low‐Dose Aspirin Induced Gastric Ulcer in a Patient With <scp>TIA</scp> : A Clinical Caution for Aspirin Therapy Without Gastroprotection
Balancing the cerebrovascular benefits of low-dose aspirin (LDA) with its significant gastrointestinal (GI) bleeding risk is a critical challenge in secondary stroke prevention. We describe a cautionary case of a 60-year-old male who, 6 months after starting LDA for a transient ischemic attack (TIA), presented with a life-threatening upper GI bleed. The patient had not been prescribed a prophylactic proton pump inhibitor (PPI). Investigations revealed a hemoglobin of 9.6 g/dL and multiple gastric ulcers on endoscopy, with negative testing for <i>Helicobacter pylori</i>. This case of a preventable, severe adverse event serves as a stark reminder that guideline-recommended gastroprotection is not optional but essential. Systematic risk assessment and PPI co-prescription in at-risk individuals are imperative for the safe and effective use of long-term antiplatelet therapy.
Authors
- Fazeela Bibi
- Muhammad Muneeb (ORCID: https://orcid.org/0000-0002-7477-0425)
- Vohra Maham Hassan
- Said Hamid Sadat
- Kainat Husain
- Aminullah Betanai
- Muhammad Ibrahim
- Bilal Aslam
- Abdullah Saud
- Khalil El Abdi
Institutions
- Mohammed V University (MA)
- University of Lahore (PK)
- Khyber Medical College (PK)
- Jawaharlal Nehru Medical College Hospital (IN)
- Kabul University (AF)
- Kabul University of Medical Sciences Abu Ali Ibn Sina (AF)
- Jinnah Medical & Dental College (PK)
- Holy Family Hospital (PK)
- University of Swabi (PK)
- University of Science and Technology Bannu (PK)
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1002/ccr3.71913
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00