Prognostic Value of Tumor-Informed Circulating Tumor DNA in HPV–Independent Head and Neck Squamous Cell Carcinoma
In this study, tumor-informed ctDNA MRD positivity was associated with worse RFS and OS in patients with HNSCC. MRD testing could serve as a noninvasive, prognostic biomarker in patients with HPV-independent HNSCC.
Authors
- Vasileios Efthymiou (ORCID: https://orcid.org/0000-0001-6139-9535)
- Jonathan J. Paly (ORCID: https://orcid.org/0000-0003-1436-9389)
- Saskia Naegele (ORCID: https://orcid.org/0000-0002-0935-7861)
- Mark A. Varvares (ORCID: https://orcid.org/0000-0002-6570-5672)
- Ross D. Merkin (ORCID: https://orcid.org/0000-0003-3418-2220)
- Allen L. Feng (ORCID: https://orcid.org/0000-0002-8040-5299)
- Giancarlo Bonora (ORCID: https://orcid.org/0000-0001-7558-3798)
- Julia Mendel
- Adam Fisch
- S. Jia
- Frank Zhang
- Pan Du
- Daniel A. Ruiz-Torres
- Daniel G. Deschler
- Daniel L. Faden
- Derrick T. Lin
- Thomas J. Roberts
Institutions
- Broad Institute (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Advanced Cell Diagnostics (United States) (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1001/jamaoto.2025.4837
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 24.82