Fitness in CLL
The increased complexity of CLL management, driven by the advent of targeted therapies, makes it necessary to redefine the concept of fitness, which until a few years ago was limited to the patient's ability to undergo chemoimmunotherapy. In the current therapeutic landscape, fitness assessment must also consider biological age, comorbidities, and frailty, which have become increasingly relevant due to evolving treatment options and a more nuanced understanding of the elderly CLL population. In this context, the general condition of the patient should be preserved with greater attention to physical activity and nutrition. This narrative review analyzed in depth all these aspects with the aim of providing insights into fitness assessments and their actualization.
Authors
- Sara Ciofini (ORCID: https://orcid.org/0009-0007-5623-1288)
- Ilaria Angeletti
- Federica Loscocco
- Alessandro Isidori (ORCID: https://orcid.org/0000-0002-5723-9229)
- Paola Picardi
- Claudia Baratè (ORCID: https://orcid.org/0000-0003-1006-2400)
- Ilaria Scortechini
- Alessandro Sanna
- Paolo Sportoletti
- Elisa Grazioli
Institutions
- University of Siena (IT)
- Foro Italico University of Rome (IT)
- University of Perugia (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Azienda Ospedaliero Universitaria Ospedali Riuniti (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Ospedali Riuniti Marche Nord (IT)
- Azienda Ospedaliera Universitaria Senese (IT)
- Nini Hospital (LB)
- ASM Terni (Italy) (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- Cancers
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3390/cancers18020342
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Associazione Italiana per la Ricerca sul Cancro