VEXAS syndrome and cancer: Insights about a possible “Tip of the Iceberg”. Ambidirectional data from the international AIDA network registries
VEXAS patients exhibit a significantly increased risk of both hematologic and non-hematologic malignancies compared with controls, particularly among those with RP, p.Met41Thr mutation, and persistent systemic inflammation.
Authors
- F. Conti
- A. Floris (ORCID: https://orcid.org/0009-0004-1671-5454)
- Vito Racanelli (ORCID: https://orcid.org/0000-0002-8639-1940)
- Guillermo Arturo Guaracha-Basáñez (ORCID: https://orcid.org/0000-0001-8060-7301)
- Amato de Paulis (ORCID: https://orcid.org/0000-0003-0347-2540)
- C. Fabiani
- Valeria Caggiano (ORCID: https://orcid.org/0000-0002-9907-4856)
- Antonio Vitale (ORCID: https://orcid.org/0000-0003-4469-7332)
- L. Cantarini
- Francesca Crisafulli (ORCID: https://orcid.org/0000-0003-0319-1538)
- Alberto Balistreri (ORCID: https://orcid.org/0000-0002-7349-9725)
- Monica Bocchia
- Alessandra Milanesi (ORCID: https://orcid.org/0000-0001-8353-5147)
- Adriana Soto-Peleteiro (ORCID: https://orcid.org/0000-0001-8959-8683)
- M. Frassi
- Juan José Alegre Sancho (ORCID: https://orcid.org/0000-0003-1641-0875)
- Carmelo Gurnari (ORCID: https://orcid.org/0000-0001-6829-5544)
- B. Frediani
- Alberto Alemanno (ORCID: https://orcid.org/0000-0001-7918-6626)
- Chiara Cardamone (ORCID: https://orcid.org/0000-0002-5713-3993)
- Lorenzo DAGNA
- Anna Sicuranza (ORCID: https://orcid.org/0000-0002-5840-2956)
- Francesco Gavioli
- Mark Beecher (ORCID: https://orcid.org/0000-0003-0381-2744)
- Pravin Hissaria (ORCID: https://orcid.org/0000-0002-0663-6312)
- A. Mayo-Juanatey (ORCID: https://orcid.org/0009-0008-5434-3021)
- Matteo Piga (ORCID: https://orcid.org/0000-0002-1126-8315)
- Jessica Sbalchiero
- Büsra Köksoy
- Marta Schermi
- Henrique A. Mayrink Giardini
- Paolo Sfriso
- Sara Bindoli
- Serena Bugatti
- Jiram Torres-Ruiz
- Rosetta Vitetta
- Thomas Panayiaris
- Francesco Placido
- José Hernández-Rodríguez
- Fatih Mulayim
- Ombretta Viapiana
- Verónica Gómez-Caverzaschi
- Francesca Silvan
- Alberto Cauli
- Marcella Prete
- Paola Triggianese
- Ilaria Zorzenon
- Vincenzo Sorrentino
- Alessandra Renieri
- Elisa Frullanti
- Abdurrahman Tufan
- Rosaria Talarico
- Olga Araújo (ORCID: https://orcid.org/0000-0003-1763-1880)
- Andrés González-García
- Ilaria Cavazzana
- Corrado Campochiaro
- Giuseppe Lopalco
- Guillermo Ruiz-Irastorza
- Samuele Rizzo
Institutions
- University of Siena (IT)
- University of Pisa (IT)
- University of Rome Tor Vergata (IT)
- Cleveland Clinic (US)
- Royal Adelaide Hospital (AU)
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- University of Cagliari (IT)
- University of Trento (IT)
- Policlinico Umberto I (IT)
- Ospedale Santa Chiara (IT)
- BioCruces Health research Institute (ES)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- CTO Andrea Alesini (IT)
- Federico II University Hospital (IT)
- Siena Biotech (Italy) (IT)
- Wojskowy Instytut Medycyny Lotniczej (PL)
- Hospital Universitario Doctor Peset (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- IRCCS Ospedale San Raffaele (IT)
- Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona (IT)
- Azienda Ospedaliera Universitaria Senese (IT)
- Policlinico Tor Vergata (IT)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Policlinico San Matteo Fondazione (IT)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Hospital Universitario Ramón y Cajal (ES)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
- Universitat de Barcelona (ES)
- University of Brescia (IT)
- Gazi University (TR)
Publication Details
- Journal
- Seminars in Arthritis and Rheumatism
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.semarthrit.2026.152932
- Primary Topic
- Otitis Media and Relapsing Polychondritis
- Type
- article
- Field-Weighted Citation Impact
- 0.00