Effect of fluoxetine on organ dysfunction and mortality in severe sepsis
Fluoxetine as adjunctive therapy in severe sepsis may reduce vasopressor dependence, attenuate inflammation, and shorten ICU stay without increasing adverse effects. Its mortality benefit remains uncertain and warrants further investigation.
Authors
- L Abou Saleh
- Ahmed S. Doghish
- Osama A. Mohammed
- M A Wareth Eissa
- Islam Abdelaal Abdelmouty Taher
- Amr Sobhy Abdel Kway
- Farouk Kamal Eldin
Institutions
- Ain Shams University (EG)
- Taif University (SA)
- Al-Azhar University (EG)
- University of Bisha (SA)
- Badr University in Cairo (EG)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1371/journal.pone.0340669
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00