Piperine improves ischemic brain injury by promoting the regulation of the AMPK/PGC-1α pathway by Apelin 13
This study showed that PIP could promote Apelin 13 to activate mitochondrial biogenesis and decreased mitochondrial functional damage. The potential mechanism of activating mitochondrial biogenesis lies in the regulation of the AMPK/PGC-1α pathway. This study not only expands the understanding of the clinical application of PIP in the treatment of IS but also provides new insights into its internal mechanism.
Authors
- Siyu Xi
- Peng Zhang (ORCID: https://orcid.org/0000-0001-8071-3729)
- Juan Liu (ORCID: https://orcid.org/0000-0002-2434-3513)
- Jing Yan
- Jiangbo Ma
- Xueyan Fu
- Yiwei Zhang
- Huiling Chen
- Guangyu Yang
- Yanzhong Li
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- China Railway Construction Machinery Research & Design Institute (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3389/fphar.2026.1746901
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningxia Province