Demonstration of the safety of a regenerative bone adhesive for cranial flap fixation in a 12-week clinically relevant sheep model
TTCP-PS was safe, producing no significant difference in adverse effects on local tissues compared to standard craniotomy with plate and screw fixation. This is the first study to quantify histological changes in the underlying cerebral cortex due to standard craniotomy technique.
Authors
- Jonathan R. Slotkin
- Eric J. Woodard
- John B. Lazor
- David A. Bichara
- Sourabh Boruah (ORCID: https://orcid.org/0000-0002-3758-616X)
- Michael C. Brown (ORCID: https://orcid.org/0000-0003-2888-8753)
- Brian Hess (ORCID: https://orcid.org/0000-0003-1264-4682)
- Smith Tr
- Kevin T. Foley
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts Eye and Ear Infirmary (US)
- Geisinger Medical Center (US)
- New England Baptist Hospital (US)
- University of Massachusetts Lowell (US)
- Harvard University (US)
- University of Tennessee Health Science Center (US)
- Semmes Murphey Foundation (US)
Publication Details
- Journal
- Journal of neurosurgery
- Published
- 2026-01-22
- DOI
- https://doi.org/10.3171/2025.8.jns243158
- Primary Topic
- Surgical Sutures and Adhesives
- Type
- article
- Field-Weighted Citation Impact
- 0.00