Assessing Generative AI Chatbots for Alcohol Misuse Support: A Longitudinal Simulation Study

Large language model (LLM)-based chatbots are increasingly used for behavioral health support. Few studies have rigorously evaluated their advice on alcohol misuse. We evaluated seven publicly available chatbots-including general-purpose and behavioral health-focused tools-in responding to alcohol misuse-related questions. Using a fictional case, we simulated longitudinal chatbot interactions over seven days, using 25 prompts derived from real-world Reddit posts. Using an evaluation framework specific to chatbots, four clinicians independently rated each chatbot's transcript along five domains: empathy, quality of information, usefulness, responsiveness, and scope awareness. Clinicians also assessed secondary dimensions, including stigmatizing language and challenging the user (vs. only validating feelings). We generated descriptive statistics on performance and identified examples of problematic output. Across all chatbots, empathy was the highest-rated domain (mean score 4.6/5) while quality of information was the lowest (mean 2.7/5). There was considerable variation in overall mean performance scores across the chatbots, ranging from 2.1 (SD 1.1) to 4.5 (SD 0.8). There were no significant differences in performance between behavioral health and general-purpose chatbots. All chatbots had one or more examples of guidance deemed inappropriate, over-stated, or inaccurate. All avoided stigmatizing or judgmental language and supported self-efficacy. Chatbots were perceived to vary widely in their ability to support individuals with alcohol misuse. While generally strong in empathy, there is room for improvement in response quality. As chatbot use expands, users and clinicians should be aware of the strengths and weaknesses of chatbots in providing advice on alcohol misuse.

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Publication Details

Journal
NEJM AI
Published
2026-01-22
DOI
https://doi.org/10.1056/aics2500676
Primary Topic
Digital Mental Health Interventions
Type
article
Field-Weighted Citation Impact
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article

Assessing Generative AI Chatbots for Alcohol Misuse Support: A Longitudinal Simulation Study

Busch Ab, Haiden A. Huskamp, Lynsay Ayer, Ateev Mehrotra et al.
NEJM AI
Digital Mental Health Interventions
article

Assessing Generative AI Chatbots for Alcohol Misuse Support: A Longitudinal Simulation Study

Busch Ab, Haiden A. Huskamp, Lynsay Ayer, Ateev Mehrotra, Lori Uscher-Pines, Jessica L. Sousa, Pushpa Raja
article en

Abstract

Large language model (LLM)-based chatbots are increasingly used for behavioral health support. Few studies have rigorously evaluated their advice on alcohol misuse. We evaluated seven publicly available chatbots-including general-purpose and behavioral health-focused tools-in responding to alcohol misuse-related questions. Using a fictional case, we simulated longitudinal chatbot interactions over seven days, using 25 prompts derived from real-world Reddit posts. Using an evaluation framework specific to chatbots, four clinicians independently rated each chatbot's transcript along five domains: empathy, quality of information, usefulness, responsiveness, and scope awareness. Clinicians also assessed secondary dimensions, including stigmatizing language and challenging the user (vs. only validating feelings). We generated descriptive statistics on performance and identified examples of problematic output. Across all chatbots, empathy was the highest-rated domain (mean score 4.6/5) while quality of information was the lowest (mean 2.7/5). There was considerable variation in overall mean performance scores across the chatbots, ranging from 2.1 (SD 1.1) to 4.5 (SD 0.8). There were no significant differences in performance between behavioral health and general-purpose chatbots. All chatbots had one or more examples of guidance deemed inappropriate, over-stated, or inaccurate. All avoided stigmatizing or judgmental language and supported self-efficacy. Chatbots were perceived to vary widely in their ability to support individuals with alcohol misuse. While generally strong in empathy, there is room for improvement in response quality. As chatbot use expands, users and clinicians should be aware of the strengths and weaknesses of chatbots in providing advice on alcohol misuse.

NEJM AIVol. 3(2)
West Los Angeles College (US), RAND Corporation (US), Harvard University (US), Brown University (US), McLean Hospital (US)
Quality Education
Openalex Percentile: Top 84%
Digital Mental Health Interventions
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