Automated Segmentation and Skin-Layer Thickness Estimation by Extracting the Optical Scattering Coefficient and Speckle Contrast Parameter from Optical Coherence Tomography Scans

These findings underscore high potential of in vivo OCT imaging supplemented with the analysis of speckle features and optical attenuation parameter for objective real-time differentiation of morphological skin layers, which is critically important for numerous applications (surgical reconstruction of skin wounds and/or burn injuries, controlled drug delivery in targeted skin layers, choice of therapy). Similar approach may be extended for diagnosing various skin diseases/pathologies.