Role of Polyethylene Glycol-Mediated Axonal Fusion in Early Recovery of Median and Ulnar Nerve Injury: A Pilot Double-Blind Randomized Clinical Trial

PEG-mediated axon fusion of median and ulnar nerves may contribute to early functional recovery and significantly improved early patient-reported outcome and quality of life. Validation of these findings in larger cohorts with adequately powered subgroup analyses is warranted.

Authors

Barite Gutama (ORCID: https://orcid.org/0000-0001-9801-6331)
Y Liu
Brian C. Drolet (ORCID: https://orcid.org/0000-0001-6459-7203)
Sriya Nemani
Lesley Wong
Douglas R. Weikert
Shady Elmaraghi
Wesley P Thayer
J Bradford Hill
for the PEG-Mediated Axon Fusion in Upper Extremity Study Group
Ronald M Cornely

Institutions

Environmental Defense Fund (US)
Apple (Israel) (IL)
University of Kentucky (US)
University of Washington (US)
Vanderbilt University Medical Center (US)

Publication Details

Journal: Journal of the American College of Surgeons
Published: 2026-01-22
DOI: https://doi.org/10.1097/xcs.0000000000001795
Primary Topic: Nerve injury and regeneration
Type: article
Field-Weighted Citation Impact: 0.00

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article

Role of Polyethylene Glycol-Mediated Axonal Fusion in Early Recovery of Median and Ulnar Nerve Injury: A Pilot Double-Blind Randomized Clinical Trial

Barite Gutama, Y Liu, Brian C. Drolet, Sriya Nemani et al.

Jan 22, 2026

Journal of the American College of Surgeons

Nerve injury and regeneration

article

Role of Polyethylene Glycol-Mediated Axonal Fusion in Early Recovery of Median and Ulnar Nerve Injury: A Pilot Double-Blind Randomized Clinical Trial

Barite Gutama, Y Liu, Brian C. Drolet, Sriya Nemani, Lesley Wong, Douglas R. Weikert, Shady Elmaraghi, Wesley P Thayer, J Bradford Hill, for the PEG-Mediated Axon Fusion in Upper Extremity Study Group, Ronald M Cornely

January 22, 2026article en

Abstract

PEG-mediated axon fusion of median and ulnar nerves may contribute to early functional recovery and significantly improved early patient-reported outcome and quality of life. Validation of these findings in larger cohorts with adequately powered subgroup analyses is warranted.

Journal of the American College of Surgeons

Environmental Defense Fund (US), Apple (Israel) (IL), University of Kentucky (US), University of Washington (US), Vanderbilt University Medical Center (US)

Openalex Percentile: Top 82%

Nerve injury and regeneration

DOI Source OpenAlex

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Role of Polyethylene Glycol-Mediated Axonal Fusion in Early Recovery of Median and Ulnar Nerve Injury: A Pilot Double-Blind Randomized Clinical Trial — Barite Gutama, Y Liu, et al. · Journal of the American College of Surgeons (2026) | TGRS Research Map | TGRS