Neonatal Purpura Fulminans: An Unusual Cause of Leukocoria, Retinal Detachment, and Vitreous Hemorrhage in Neonates

Neonatal purpura fulminans is a rare but life-threatening thrombotic disorder caused by congenital deficiencies of protein C. It presents with hemorrhagic necrosis of the skin due to the underlying dysfunction of coagulation. Ocular findings include leukocoria, chemosis, periorbital edema, posterior synechia, vitreous hemorrhage, retinal detachment, and retinal dysplasia. Sometimes, leukocoria may occur before any other manifestations. Here, we describe a case of neonatal purpura fulminans characterized by multiple purpuric skin lesions, leukocoria, vitreous hemorrhage, and total retinal detachment.