Amniotic fluid stem cell-derived extracellular vesicles enhance functional recovery of neurogenic bladder and neurovascular plasticity after cerebral ischemia in rats
hAFSC-EV treatment improves neurogenic bladder dysfunction and cerebral ischemia post-MCAO, potentially through reducing infarct volume and BBB disruption, enhancing neurogenesis and angiogenesis in the ischemic brain, and modulating the expression of bladder BDNF, β3-adrenoceptor, adenylate cyclase and muscarinic receptors.
Authors
- Yi-Haou Lin
- T. Y. Hsieh (ORCID: https://orcid.org/0009-0003-6242-5098)
- Ching-Chung Liang
- Steven W Shaw
- Yung-Hsin Huang
- Tsong-Hai Lee
- Hsien-Ming Wu
Institutions
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Life Sciences
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1016/j.lfs.2026.124225
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00