Clinical complete response and predictive factors in HER2-positive early breast cancer treated with neoadjuvant chemotherapy aimed at omission of surgery: an exploratory analysis of the JCOG1806 trial
ER-negativity, an IHC score of 3 + , and a higher histological grade were independent predictors of a cCR. Identifying these features may improve the feasibility and safety of surgery omission for patients with HER2-positive early breast cancer.
Authors
- Keita Sasaki (ORCID: https://orcid.org/0009-0005-5100-3863)
- Taro Shibata
- Ryo Sadachi (ORCID: https://orcid.org/0009-0009-9536-1506)
- Noriko Mitome (ORCID: https://orcid.org/0009-0000-0082-9028)
- Yasuaki Sagara (ORCID: https://orcid.org/0000-0001-5705-1739)
- Kaori Terata
- Tomomi Fujisawa (ORCID: https://orcid.org/0000-0002-8437-5808)
- Tadahiko Shien (ORCID: https://orcid.org/0000-0003-3202-5512)
- Kazuki Sudo
- Toshiyuki Ishiba (ORCID: https://orcid.org/0000-0002-8709-4972)
- Sakai Takehiko
- Yoichi Naito
- Kazuki Nozawa
- Akihiko Shimomura
- Yukinori Ozaki
- Fumikata Hara
- Hiroji Iwata
Institutions
- Nagoya City University (JP)
- National Center for Global Health and Medicine (JP)
- Okayama University Hospital (JP)
- Hiroshima University Hospital (JP)
- Gunma Prefectural Cardiovascular Center (JP)
- Akita University Hospital (JP)
- Aichi Cancer Center (JP)
- National Cancer Center Hospital East (JP)
- Japan Clinical Cancer Research Organization (JP)
- Tokyo National Hospital (JP)
- Japanese Foundation For Cancer Research (JP)
Publication Details
- Journal
- International Journal of Clinical Oncology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1007/s10147-026-02967-7
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00