Plasma Proteomics and Sensitive Imaging Biomarkers of Vascular Brain Injury
This cohort and Mendelian randomization study identified several proteins significantly associated with FW and PSMD, which are potential imaging biomarkers of ischemia, neuroinflammation, and axonal degeneration. Mendelian randomization analyses suggested potential causal effects of certain proteins on white matter hyperintensities and stroke, highlighting the need for functional studies to explore whether elevated protein levels represent protective mechanisms or contribute to brain injury.
Authors
- Valborg Guðmundsdóttir (ORCID: https://orcid.org/0000-0002-7459-1603)
- Yineng Zhu
- Joseph Loureiro (ORCID: https://orcid.org/0000-0001-7222-9160)
- Emer R. McGrath (ORCID: https://orcid.org/0000-0002-3589-2964)
- Robert E. Gerszten (ORCID: https://orcid.org/0000-0002-6767-7687)
- Muralidharan Sargurupremraj (ORCID: https://orcid.org/0000-0003-1684-3750)
- L. Lenore Launer
- L Jennings
- ZSU-ZSU CHEN
- Sudha Seshadri
- Usman Tahir
- Pauline Maillard
- Vilmundur Gudnason
- Stephanie Debette
- Ramachandran S Vasan
- Lars Forsberg
- Charles DeCarli
- Claudia L. Satizabal
- Alexa S Beiser
- Qiong Yang
Institutions
- Boston University (US)
- Beth Israel Deaconess Medical Center (US)
- Université de Bordeaux (FR)
- Inserm (FR)
- University of Iceland (IS)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Karolinska Institutet (SE)
- Bordeaux Population Health (FR)
- Institute for Neurodegenerative Disorders (US)
- Novartis (United States) (US)
- National Institute on Aging (US)
- Icelandic Heart Association (IS)
- The University of Texas at San Antonio (US)
- University of California, Davis (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-22
- DOI
- https://doi.org/10.64898/2026.01.19.26344369
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hjartavernd
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute